How do you go about making a vaccine? – I Part
How do you go about making a vaccine? We received this very pertinent question from a sci-fi author a few weeks ago, and thought it was worth a new short blog series! This month we cover the early R&D stages of vaccine discovery, while in the next blog, we’ll talk...
The making of dengue virus: NS4 & NS5
The non-structural proteins of dengue, although relatively small, have multiple assorted roles. In last month’s blog, we have seen how NS2 and NS3 each play multiple roles in virus propagation and host immunomodulation. This month we address NS4 and NS5, two...
Evolve or get zapped
In a 2017 Nature publication (Takata et al.), a team of virologists led by Professor Paul D. Bieniasz (The Rockefeller University) found that zinc-finger antiviral protein (ZAP) discriminates self from nonself (viral) RNAs based on their CG dinucleotide content. Now,...
The making of dengue virus: NS2 & NS3
In last month’s blog, we have seen how the glycoprotein NS1 plays an essential role in flavivirus RNA replication. This month, we continue with this theme and describe other two non-structural proteins of dengue virus, NS2 and NS3. NS2, viral RNA synthesis, and virion...Page 11 of 30