Gut bacteria prevent and cure rotavirus infection
We all know by now how the microbiota can positively or negatively influence the course of a wide range of bacterial infections. However, maybe less predictably, the microbiota can also influence viral infection. A recent study has serendipitously found that the...
Antiviral drug discovery – Part 2: From candidates to investigational drugs
In this three-part blog series, we present the typical workflow of an antiviral discovery program, from the initial identification of antiviral molecules in vitro (Part 1) to preclinical testing (Part 2) and assessing the onset of drug resistance (Part 3). These early...
The making of dengue virus: NS1
The RNA genome of dengue virus (DENV) encodes seven nonstructural proteins that are essential for viral replication (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5). In this month’s post, we dissect the characteristics and roles of NS1, a multifunctional glycoprotein that...
Gut microbiome powers flu vaccination
Our gut talks the language of our immune system, playing a key role in the complex mechanisms of immunoregulation. If antibiotics are essential to kill pathogenic bacteria, it is also true that they change the composition and metabolism of the gut microbiome, the...Page 12 of 30