Antiviral drug discovery – Part 1: From no drug to promising candidates
From target to drug Traditionally, antiviral drug discovery has started from detailed knowledge of a specific viral target. Proteins that are critical for a virus’ life cycle (e.g., polymerase, protease, and envelope) are first characterised, ideally by...
The making of dengue virus: the structural proteins
A brief jaunt through the dengue life cycle During DENV entry into the host cell, the envelope protein binds to the cognate receptor and triggers DENV endocytosis and internalization within an endosome. Next, low endosomal pH induces changes in the conformation of the...
IFITMs and the dangers of IFN
Our cells use a wide variety of mechanisms to prevent virus infection. These mechanisms are usually mediated by proteins that are upregulated upon induction of interferon. Among these interferon-stimulated effectors, the IFITM (interferon-induced transmembrane)...
What determines susceptibility to virus infection?
We all have different susceptibility Individuals differ in their susceptibility to viral infections, and the clinical course of any patient infected with a virulent virus is ultimately determined by the complex patient-virus interaction. And this makes perfect sense....Page 12 of 29