How to look at… Part 2/3: Viral replication
Gaining access to the cell is a prerequisite to establishing infection. Replication, however, is when a virus subverts the cell to generate multiple copies of itself. The nature of the virus genome determines the steps required to reach this stage. Positive-stranded...
The virus of the month: The making of dengue virus
The making of dengue virus Dengue virus (DENV) belongs to the family Flaviviridae (genus Flavivirus) and is transmitted to humans by Aedes mosquitoes (mainly Aedes aegypti). DENV infection is usually characterized by fever and severe joint pain, but more serious...
The Mysterious Origin of Viruses
Viruses: Evolution’s cheaters Viruses can be considered genetic parasites that hijack the resources of their cellular hosts. They are evolution’s cheaters. And they are doing well with this strategy: viruses parasitize all forms of cellular life and are the most...
How to look at … Part 1/3: Viral entry
Understanding at what stage of a virus life cycle a compound or a restriction factor acts is critical in the discovery process. In drug discovery, this aspect can be a bottleneck for hits generated via phenotypic screenings, but even when the viral of cellular targets...Page 14 of 30