The making of dengue virus: NS2 & NS3

by Virology Research Services | Oct 31, 2019 | Virus of the Month

In last month’s blog, we have seen how the glycoprotein NS1 plays an essential role in flavivirus RNA replication. This month, we continue with this theme and describe other two non-structural proteins of dengue virus, NS2 and NS3. NS2, viral RNA synthesis, and virion...

Antiviral drug discovery – Part 3: When the virus fights back – antiviral resistance

by Virology Research Services | Oct 31, 2019 | Virus Methods

In this three-blog series, we present the typical workflow of an antiviral discovery program, from the initial identification of antiviral molecules in vitro (Part 1) to preclinical testing (Part 2) and assessing the onset of drug resistance (Part 3). These early...

Gut bacteria prevent and cure rotavirus infection

by Virology Research Services | Oct 31, 2019 | VRS Blog

We all know by now how the microbiota can positively or negatively influence the course of a wide range of bacterial infections. However, maybe less predictably, the microbiota can also influence viral infection. A recent study  has serendipitously found that the...

Antiviral drug discovery – Part 2: From candidates to investigational drugs

by Virology Research Services | Sep 30, 2019 | Virus Methods

In this three-part blog series, we present the typical workflow of an antiviral discovery program, from the initial identification of antiviral molecules in vitro (Part 1) to preclinical testing (Part 2) and assessing the onset of drug resistance (Part 3). These early...

The making of dengue virus: NS1

by Virology Research Services | Sep 30, 2019 | Virus of the Month

The RNA genome of dengue virus (DENV) encodes seven nonstructural proteins that are essential for viral replication (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5). In this month’s post, we dissect the characteristics and roles of NS1, a multifunctional glycoprotein that...