The making of dengue virus: NS4 & NS5
The non-structural proteins of dengue, although relatively small, have multiple assorted roles. In last month’s blog, we have seen how NS2 and NS3 each play multiple roles in virus propagation and host immunomodulation. This month we address NS4 and NS5, two...
Evolve or get zapped
In a 2017 Nature publication (Takata et al.), a team of virologists led by Professor Paul D. Bieniasz (The Rockefeller University) found that zinc-finger antiviral protein (ZAP) discriminates self from nonself (viral) RNAs based on their CG dinucleotide content. Now,...
The making of dengue virus: NS2 & NS3
In last month’s blog, we have seen how the glycoprotein NS1 plays an essential role in flavivirus RNA replication. This month, we continue with this theme and describe other two non-structural proteins of dengue virus, NS2 and NS3. NS2, viral RNA synthesis, and virion...
Antiviral drug discovery – Part 3: When the virus fights back – antiviral resistance
In this three-blog series, we present the typical workflow of an antiviral discovery program, from the initial identification of antiviral molecules in vitro (Part 1) to preclinical testing (Part 2) and assessing the onset of drug resistance (Part 3). These early...Page 15 of 33