Dengvaxia: what went wrong?
Dengvaxia: what went wrong? Dengue fever is caused by four related but distinct viruses (dengue serotypes 1–4). These serotypes differ in their antigenicity and trigger unique antibody responses. Initial infection with one dengue serotype causes a mild flu-like...
Do vaccines spread?
Do vaccines spread? A live attenuated vaccine is effectively still a virus, and as such it shares with viruses the ability to spread. This is an important and often overlooked concept that is covered with much clarity by Bull, Smithson and Nuismer in Trends in...
Vaccine Research: Then and Now
Vaccine Research: Then and Now If life expectancy has greatly increased in the past century, this is largely due to vaccines, which, according to the WHO, save 6 million people from death each year. This terrific success, unfortunately, has led many to forget about...
How to survive a phenotypic antiviral screening
How to survive a phenotypic antiviral screening Antiviral screening is a powerful tool to identify new compounds and therapeutic targets against viruses. Traditionally, an antiviral screening targets a viral protein critical for replication and uses high-throughput in...Page 28 of 29