The search for a dengue vaccine: What have we learned?
The search for a dengue vaccine: What have we learned? The ambiguous role of antibodies is a major problem in the development of a dengue vaccine. First, heterotypic, non-neutralizing antibodies can cause antibody-dependent enhancement (ADE), leading to increased...
Dengvaxia: what went wrong?
Dengvaxia: what went wrong? Dengue fever is caused by four related but distinct viruses (dengue serotypes 1–4). These serotypes differ in their antigenicity and trigger unique antibody responses. Initial infection with one dengue serotype causes a mild flu-like...
Do vaccines spread?
Do vaccines spread? A live attenuated vaccine is effectively still a virus, and as such it shares with viruses the ability to spread. This is an important and often overlooked concept that is covered with much clarity by Bull, Smithson and Nuismer in Trends in...
Vaccine Research: Then and Now
Vaccine Research: Then and Now If life expectancy has greatly increased in the past century, this is largely due to vaccines, which, according to the WHO, save 6 million people from death each year. This terrific success, unfortunately, has led many to forget about...Page 29 of 30