It’s the virus, stupid (?)
It’s the virus, stupid (?) Direct acting antivirals (DAAs) are among the most successful drugs ever developed. It is thanks to DAAs that HIV is no longer a death sentence, and we can now clear hepatitis C virus from many chronically infected patients. Unfortunately,...
Engineered Influenza Virus as a Weapon Against Cancer
Engineered Influenza Virus as a Weapon Against Cancer What if a virus could be used to selectively replicate in – and kill – cancer cells, without harming the normal tissues? Some researchers are aiming to do exactly this by genetically engineering oncolytic viruses...
The search for a dengue vaccine: What have we learned?
The search for a dengue vaccine: What have we learned? The ambiguous role of antibodies is a major problem in the development of a dengue vaccine. First, heterotypic, non-neutralizing antibodies can cause antibody-dependent enhancement (ADE), leading to increased...
Dengvaxia: what went wrong?
Dengvaxia: what went wrong? Dengue fever is caused by four related but distinct viruses (dengue serotypes 1–4). These serotypes differ in their antigenicity and trigger unique antibody responses. Initial infection with one dengue serotype causes a mild flu-like...Page 32 of 33