What determines susceptibility to virus infection?

by Virology Research Services | Jul 29, 2019 | VRS Blog

We all have different susceptibility Individuals differ in their susceptibility to viral infections, and the clinical course of any patient infected with a virulent virus is ultimately determined by the complex patient-virus interaction. And this makes perfect sense....

The making of dengue virus: 5’UTR

by Virology Research Services | Jul 29, 2019 | Virus of the Month

The DENV RNA genome encodes a single long open reading frame that encodes multiple viral proteins. Examining the DENV genome, the first region that we encounter is the 5′ untranslated region (5′-UTR). This is a short but highly structured sequence of between 95 to 101...

How to look at… Part 3/3: Viral assembly and release

by Virology Research Services | Jul 29, 2019 | Virus Methods

In this series of three blogs, we present different assays and techniques that can be used to narrow down the mode of action of compounds or cellular proteins that interfere with the virus life cycle, and we focus on procedures that – with some optimisation – can be...

How to look at… Part 2/3: Viral replication

by Virology Research Services | Jun 26, 2019 | Virus Methods

Gaining access to the cell is a prerequisite to establishing infection. Replication, however, is when a virus subverts the cell to generate multiple copies of itself. The nature of the virus genome determines the steps required to reach this stage. Positive-stranded...

The virus of the month: The making of dengue virus

by Virology Research Services | Jun 26, 2019 | Virus of the Month

The making of dengue virus Dengue virus (DENV) belongs to the family Flaviviridae (genus Flavivirus) and is transmitted to humans by Aedes mosquitoes (mainly Aedes aegypti). DENV infection is usually characterized by fever and severe joint pain, but more serious...