IFITMs and the dangers of IFN
Our cells use a wide variety of mechanisms to prevent virus infection. These mechanisms are usually mediated by proteins that are upregulated upon induction of interferon. Among these interferon-stimulated effectors, the IFITM (interferon-induced transmembrane)...
What determines susceptibility to virus infection?
We all have different susceptibility Individuals differ in their susceptibility to viral infections, and the clinical course of any patient infected with a virulent virus is ultimately determined by the complex patient-virus interaction. And this makes perfect sense....
The making of dengue virus: 5’UTR
The DENV RNA genome encodes a single long open reading frame that encodes multiple viral proteins. Examining the DENV genome, the first region that we encounter is the 5′ untranslated region (5′-UTR). This is a short but highly structured sequence of between 95 to 101...
How to look at… Part 3/3: Viral assembly and release
In this series of three blogs, we present different assays and techniques that can be used to narrow down the mode of action of compounds or cellular proteins that interfere with the virus life cycle, and we focus on procedures that – with some optimisation – can be...Page 17 of 33