The virus of the month: The making of dengue virus
The making of dengue virus Dengue virus (DENV) belongs to the family Flaviviridae (genus Flavivirus) and is transmitted to humans by Aedes mosquitoes (mainly Aedes aegypti). DENV infection is usually characterized by fever and severe joint pain, but more serious...
The Mysterious Origin of Viruses
Viruses: Evolution’s cheaters Viruses can be considered genetic parasites that hijack the resources of their cellular hosts. They are evolution’s cheaters. And they are doing well with this strategy: viruses parasitize all forms of cellular life and are the most...
How to look at … Part 1/3: Viral entry
Understanding at what stage of a virus life cycle a compound or a restriction factor acts is critical in the discovery process. In drug discovery, this aspect can be a bottleneck for hits generated via phenotypic screenings, but even when the viral of cellular targets...
The viral system of the month: Adeno-associated derived vectors
From concept to reality: How a virus is helping to advance gene therapy This month the FDA approved Zolgensma (Novartis), the first gene therapy for spinal muscular atrophy in children. While the treatment price – $2.125 million – is making most headlines, here we...Page 18 of 33